"Sirtuin proteins (SIRTs) are created when the body recognizes a caloric deficit, they do three things we are concerned with:
1) they run around the body cleaning up old, dead cells; and the innards of cells that are sickly. They send the detritus to be burned as fuel. And, in the process of cleaning up they can make great improvements in our health.
2) they support fat burning, in fact they appear to be critical to making the body burn fat and preserve muscle
3) for some of us, they reduce feelings of hunger
Sounds great, doesn't it? It is. The trick is that the body only generates them for a fairly short time. After an average of 40 hours, if the body is still in a calorie deficit, it stops producing SIRTs and changes over to burning fat and muscle.
By eating very low one day, we invoke the SIRTs and burn fat (and get a nice internal dusting and cleaning). By eating high the next day, we turn off the calorie deficit and prevent muscle being used for fuel. That is the magic to the rotation.
Gradually, over time, we accumulate enough SIRTs that they hang around and keep working on UD. At that point, weight loss usually speeds up a bit...even if it does not speed up, it becomes very stable and predictable.
When we have a - ahem - body-full of SIRTs, it takes about two weeks to burn them all away. That is why going on vacation for a week or so may cause a bounce, but returning to the rotation and losing the bounce is usually very easy.
I hope that helps."
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Taken from this blog
http://www.lowcarbfriends.com/bbs/juddd/794318-magical-gene-what.html
about halfway down
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